In pursuit of gaining a competitive edge, gene switch developers are presently undertaking several initiatives to expand their existing capabilities and augment respective product portfolios.
The products considered in this analysis have been scored based on several relevant parameters, such as supplier strength (based on number of years of experience), product competitiveness (based on technology licensing option, application area, target therapy (s), highest phase of development and target indication). Driven by the increasing adoption of gene switches to overcome the safety-related concerns associated with engineered cell therapies, the gene switch market is likely to witness significant growth in the future.
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The relative position of different products in the figure is based on the scores assigned to them for their supplier strength and product competitiveness. Based on our proprietary scoring criteria, the ZF-transcription factors developed by Sangamo Biosciences and RNA switches developed by aceRNA technologies emerged as relatively competent products, amongst all the currently available gene switch platforms. ZF-transcription factors are protein-based gene switches that are majorly used for regulation of gene expression and are activated by tamoxifen. Further, the RNA switches developed by aceRNA technologies are used for various application areas, including management of treatment related toxicity, cell proliferation / cell persistence and regulation of gene expression.
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